SR-17018 Frequently Asked Questions: Everything Researchers Need to Know

General Compound Information

What is SR-17018?
SR-17018 is a highly selective, biased agonist of the kappa-opioid receptor (KOR). It is synthesized strictly for laboratory and in-vitro research.

What is its CAS Number?
The CAS registry number for SR-17018 is 1421249-69-5.

How does it differ from traditional opioids?
Traditional opioids target the mu-opioid receptor (MOR), causing euphoria and respiratory depression. SR-17018 targets KOR, offering analgesia without addiction potential or fatal respiratory depression.

Safety and Pharmacology

Is SR-17018 addictive?
No. Preclinical research indicates that KOR agonists do not trigger dopamine reward pathways and possess no abuse liability.

What is biased agonism?
It is the ability of a molecule to activate specific pathways within a receptor while ignoring others. SR-17018 favors the G-protein (analgesic) pathway over the beta-arrestin (dysphoric) pathway.

Handling and Storage

How should I store the powder?
Store tightly sealed in a cool, dry place away from direct light. For long-term stability, storage at -20°C in a desiccated environment is recommended.

What vehicles are best for dissolving SR-17018?
Due to its lipophilic nature, researchers commonly use low concentrations of DMSO or Tween-80 combined with saline for in-vivo models.

Purchasing and Compliance

Is this for human consumption?
Absolutely not. SR-17018 is an experimental research chemical. Human or veterinary use is strictly prohibited and highly dangerous.

Do you provide a Certificate of Analysis?
Yes, every batch is verified via HPLC to ensure ≥99% purity, and CoAs are available for researchers to document their protocols.