Question 1

What is SR-17018?

Accepted Answer

SR-17018 is a highly selective, biased agonist of the kappa-opioid receptor (KOR). It is an experimental compound synthesized strictly for laboratory research, offering a unique profile that separates analgesia from dysphoria via G-protein bias.

Question 2

What is the CAS Number?

Accepted Answer

The CAS registry number for SR-17018 is 1421249-69-5.

Question 3

How do you guarantee purity?

Accepted Answer

Every batch of our SR-17018 undergoes rigorous third-party analytical testing, including HPLC and NMR spectroscopy. We guarantee a purity of ≥99.5%, and a Certificate of Analysis is available upon request.

Question 4

Is SR-17018 an addictive opioid?

Accepted Answer

No. While it is an opioid receptor agonist, it targets the kappa (KOR) receptor, not the mu (MOR) receptor. KOR agonists do not trigger dopamine-driven reward pathways, meaning they possess virtually zero abuse liability.

Question 5

Powder vs. Capsules: Which should I order?

Accepted Answer

Powder is recommended for in-vitro assays or when custom vehicle formulation is required. Capsules (10mg pre-measured) are recommended for models requiring consistent, precise dosing without high-precision balances.

Question 6

What is biased agonism?

Accepted Answer

Biased agonism is when a ligand preferentially activates one signaling pathway downstream of a receptor over another. SR-17018 is biased toward G-protein signaling and away from β-arrestin recruitment, which separates therapeutic effects from side effects like sedation and dysphoria.

Question 7

How does SR-17018 differ from morphine?

Accepted Answer

Morphine targets the mu-opioid receptor (MOR), driving the dopaminergic reward pathway responsible for opioid addiction. SR-17018 targets the kappa-opioid receptor (KOR), which suppresses rather than activates the reward pathway, eliminating abuse liability.

Question 8

How does SR-17018 differ from U-50,488 or salvinorin A?

Accepted Answer

Traditional KOR agonists like U-50,488 and salvinorin A activate both G-protein and β-arrestin pathways, producing dysphoria and rapid tolerance. SR-17018 is biased toward G-protein signaling, preserving analgesia while sparing dysphoria and tolerance.

Question 9

What research applications is SR-17018 used for?

Accepted Answer

SR-17018 is used in pain pharmacology, addiction-recovery models, mood and stress research, biased-agonism mechanism studies, and as a comparator against U-50,488 and other reference KOR agonists.

Question 10

Is SR-17018 legal to purchase?

Accepted Answer

SR-17018 is sold internationally as a research chemical. It is the buyer's responsibility to verify compliance with their local, state, and national regulations. It is not a controlled substance in most jurisdictions.

Question 11

How should I store SR-17018?

Accepted Answer

For short-term use, store in a cool, dry place away from light. For long-term stability, store at -20°C in a desiccated environment. Properly stored, SR-17018 remains stable for 24+ months.

Question 12

What is the solubility profile?

Accepted Answer

SR-17018 is highly lipophilic and poorly water-soluble. Researchers typically use DMSO (≤5%) or Tween-80 vehicles before diluting with saline. Proper homogenization is necessary.

Question 13

What payment methods do you accept?

Accepted Answer

For privacy and security, we primarily accept major cryptocurrencies (Bitcoin, Monero, Litecoin). Institutional bank transfers are available for academic and corporate laboratory orders.

Question 14

Do you ship internationally?

Accepted Answer

Yes, we ship to most international jurisdictions. The buyer is responsible for ensuring compliance with local importation laws regarding research chemicals.

Question 15

Do you provide a Certificate of Analysis?

Accepted Answer

Yes. Every order ships with a batch-specific Certificate of Analysis (CoA) documenting HPLC purity, NMR structural verification, and identity confirmation.

Question 16

What is the shelf life of SR-17018?

Accepted Answer

When stored at -20°C in a sealed, desiccated container, SR-17018 maintains ≥99% purity for at least 24 months. At room temperature, expect 6–12 months of usable shelf life.

Question 17

Can SR-17018 cause respiratory depression?

Accepted Answer

No. Respiratory depression is mediated through the mu-opioid receptor (MOR). As a selective KOR agonist, SR-17018 does not engage MOR signaling and therefore does not produce respiratory depression in preclinical models.

Question 18

Is SR-17018 a controlled substance?

Accepted Answer

SR-17018 is not currently scheduled by the U.S. DEA or most international regulatory bodies. However, regulatory status can change — buyers must verify the current status in their jurisdiction.

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